Identification of distinct receptors for two hemopoietic growth factors (granulocyte colony-stimulating factor and multipotential colony-stimulating factor) by chemical cross-linking.
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چکیده
منابع مشابه
Identification Through Chemical Cross - Linking of Distinct Granulocyte - Macrophage Colony - Stimulating Factor and Interleukin - 3 Receptors on Myeloid Leukemic Cells
Granulocyte/ macrophage colony-stimulating factor (GMCSF) and interleukin-3 (11-3) each bind specifically to a small number of high-affinity receptors present on the surface of the cells of the acute myelogenous leukemia line, KG-i . Through chemical cross-linking of IL-3 and GM-CSF to KG-i cells, we identified distinct binding proteins for each of these cytokines with approximate molecular mas...
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In the background section of their abstract, Woei-Cherng Shyu and associates state that because granulocyte colony-stimulating factor (G-CSF) has anti-inflammatory and neuroprotective properties and the capacity to mobilize stem cells, it has the potential to be used in treatment of stroke. However, there are limited data about the effects of G-CSF on hemostasis. It has been suggested that G-CS...
متن کاملGranulocyte colony stimulating factor.
Granulocyte colony-stimulating factor was discovered during attempts to define the normal regulators present in cell supernatants that could induce terminal differentiation of the murine myeloid leukemic cell line WEHI-3B D+. The purification and subsequent cloning of both murine and human G-CSF allowed the normal functions of this molecule to be elucidated and indicated that it was a relativel...
متن کاملRegulation of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor expression by oncostatin M.
Oncostatin M (OM) is structurally and functionally related to a subclass of hematopoietic cytokines including leukemia-inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), granulocyte colony-stimulating factor (G-CSF), and interleukin-6 (IL-6). Using human endothelial cells (HEC) as a model for cytokine regulation of hematopoietic growth factor expression, we tested OM as an inducer of ...
متن کاملGranulocyte colony-stimulating factor enhances interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.
In cultures of spleen cells from normal mice, recombinant human granulocyte colony-stimulating factor (G-CSF) supported the formation of multipotential blast cell colonies. Serial replating of the blast cell colonies in the presence of G-CSF, however, failed to demonstrate any direct effect of G-CSF on murine multipotential progenitors. We therefore examined the effects of G-CSF in combination ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1986
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)67251-5